A recent study indicates that individuals who discontinue blockbuster slimming jabs like semaglutide or tirzepatide may regain reduced body mass at a significantly accelerated pace than those who halt conventional diet and exercise programs.
Published data in a leading medical journal shows that while obese people can lose about a fifth of their total mass while undergoing treatment, the weight returns at an average rate of 0.8 kg per month after stopping.
"People purchasing these treatments must be cognizant of the risk of fast rebound weight gain when the medication ends," warns researcher Dr. Susan Jebb.
That rate of regain implies a reversion to pre-treatment weight within about a year and a half.
Analyzing Approaches
The research, which looked at 37 of trials involving thousands of participants, contrasted the effects of the injectable medications with older methods.
The team note that people who lose weight through lifestyle changes alone usually see a less rapid creep back—approximately 100 grams monthly—after stopping.
Understanding the Quick Rebound
Doctors suggest the mechanism of the injections explains the amplified regain.
These medications mimic a body's own chemical called GLP-1, which controls appetite.
"Long-term administration of GLP-1 concentrations several times higher than normal could lead to the system to produce less of its own natural hormone, and could reduce sensitivity to its effects," noted Dr. Adam Collins, a nutrition expert.
"Stopping of this hormone supplement leads to hunger is no longer kept in check, making excessive eating far more likely."
An Ongoing Condition?
The NHS recommend the injections for individuals with weight-linked health risks, accompanied by recommended lifestyle changes.
Professionals argue that, due to the significant potential of relapse, the therapy is often ongoing.
This view is supported by drug manufacturers, who say that the findings "highlight the long-term nature of excess weight," comparing it to managing conditions like hypertension.
Patient Accounts
People who have come off the medication describe a sudden resurgence of hunger.
"It was like a switch flipping and you're instantly ravenous," said a patient.
The struggle is exacerbated if users have not established lasting lifestyle or habit changes during treatment.
Widespread Interest
Figures suggest that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is more common among women compared to men.
- The 40s and 50s age group shows the highest usage rates.
- A large proportion access the drugs through private prescriptions rather than the NHS.
In conclusion, researchers stress that while these medications are effective tools for shedding pounds, they are not a standalone solution and maintained weight loss likely depends on combined lifestyle support.
